Director, Investigative Toxicology Lead 377 views

This is a senior leadership position in the Global Investigative Toxicology line (~30 colleagues) and the Global Drug Safety Research and Development (DSRD) organization (~450 colleagues). The incumbent will be responsible for leading strategic and business initiatives within the Investigative Toxicology discipline that champion and expand the scientific breadth and depth of the discipline, explore and implement new in vitro models and technologies, contribute to de-risking toxicology issues in portfolio programs across 7 Therapeutic Areas and all drug development stages (idea-registration) and developing the next generation of Investigative Toxicology leaders. This role will also identify and cultivate effective partnerships with other global disciplines within DSRD (such as Biomarkers and Pathology), as well as nonclinical and clinical disciplines outside of DSRD, facilitating the nonclinical to clinical translation of investigative toxicology endpoints or mechanistic hypotheses.

The incumbent will have 10-15 years of experience in investigation toxicology, preferably in the biopharmaceutical industry with a strong interest in advancing the Investigative Toxicology discipline in a global model. Prior scientific experience in one or more of these scientific areas is a plus: complex in vitro models/microtissues/organoids, organ-specific microfluidic in vitro models, nonclinical genomics and expression profiling, high throughput safety screening assays, organ-specific in vitro models for compound screening or differentiation, mechanistic de-risking of unexpected toxicology findings and evaluation of clinical translation, or the development of new in vitro safety screens for immuno-oncology, gene therapy or other novel therapeutic modalities.

To maximize recruitment potential, the position can be located at any of the DSRD sites (Groton CT, Andover/Cambridge MA or La Jolla CA). The incumbent will have 5-10 direct reports (influenced by the incumbent’s experience and location).

  • Reports to the Executive Director, Global Investigative Toxicology.
  • A member of the Global Investigative Leadership Team (LT).
  • Effectively collaborates and communicates with other LT members to deliver the portfolio, balance workload across sites and develop colleagues.
  • Draws from Global Investigative Toxicology staff (considering skill set and workload) to deliver investigative toxicology data with speed and quality to efficiently support portfolio progression/mechanistic understanding.
  • Recruits, trains, develops, motivates highly skilled colleagues across Global Investigative Toxicology.
  • Positions DSRD to rapidly and effectively evaluate nonclinical assays or study endpoints, identifies key data gaps and prioritizes them to improve the overall quality and mechanistic understanding of investigative toxicology assays and data interpretation.
  • Engages in critical scientific and business evaluation of new technologies, in vitro assays, and scientific or regulatory advancements in the development of small and large molecule therapeutics.
  • Responsible for appropriate training, performance management and other business-related activities of their direct reports. Performs all regulatory responsibilities in compliance with applicable standards.
  • Provides oversight of laboratory expenditures and operations, including laboratory safety and equipment calibration, data capture, QC reporting and archiving.
  • Represents DSRD on relevant teams, providing scientific guidance of projects or strategic leadership.
  • Models DSRD leadership behaviors and values and fosters a rewarding scientific climate.

Relocation is available

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